John Latham

Assistant Professor

What I do

My lab is currently focused on solving the structure, function, and biosynthesis of the unknown Mycobacterial metabolite dubbed mycofactocin.

Professional Biography

PhD - University of New Mexico (2012)
Postdoc - University of California, Berkeley (2013-15)

Degree(s)

  • Ph.D., Chemistry, University of New Mexico, 2012
  • MS, Chemistry, Eastern New Mexico University, 2008
  • BS, Chemistry, Eastern New Mexico University, 2007

Licensure / Accreditations

  • New Mexico Teaching Liscensure

Featured Publications

  • Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC
  • Mechanistic elucidation of the mycofactocin-biosynthetic radical S -adenosylmethionine protein, MftC
  • Mycofactocin biosynthesis proceeds through 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); direct observation of MftE specificity towards MftA*
  • Spectroscopic and Electrochemical Characterization of the Mycofactocin Biosynthetic Protein, MftC, Provides Insight into its Redox Flipping Mechanism
  • MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin