Susan E. Sadler

Associate Professor

What I do

Over the years, my lab team has studied the early molecular events that trigger meiotic cell division. We have collected evidence showing that hormone-induced triggering mechanisms include:
- inhibition of adenylyl cyclase (the enzyme that synthesizes cAMP) independent of the G-alpha-i subunit of heterotrimeric G protein (by progesterone and IGF-1)
- stimulation of cGMP-inhibited phosphodiesterase type 3 (by insulin, IGF-1 and ras protein)
migration of p21ras protein to the oocyte membrane (by insulin)
- receptor-mediated endocytosis of the insulin/IGF-1 receptor (by insulin and IGF-1)
- inhibition of farnesyl transferase activity (by insulin and IGF-1) [this is the enzyme that attaches lipid anchors to the p21ras protein]

We have also evaluated how oocyte membrane fluidity and cholesterol-rich, low-density membrane domains might be affected by inducing hormones and how follicular cells that surround developing oocytes may respond to hormone signals by producing nitric oxide.

Specialization(s)

biochemistry, cell biology, Signal Transduction, Hormone Signaling, Oocyte Maturation

Professional Biography

After earning a BA in Chemistry from The Colorado College, I earned my PhD in Pharmacology from University of Colorado School of Medicine. My teaching/research career began with teaching in the Physician Assistant program at CU School of Medicine in a joint appointment between Pharmacology and Pediatrics, before joining the faculty at University of Denver.

Degree(s)

  • Ph.D., Pharmacology, Univ of Colorado School of Medicine, 1982
  • BA, Chemistry, The Colorado College, 1977

Research

Using biochemical, pharmacological, immunological and microscopic techniques, the early signaling events that trigger oocyte maturation have been investigated.

Key Projects

  • Dynamic Caveolin-Caveolae-Steroid Signaling Complexes

Presentations

Sadler, S. E. (2015). "Let's Talk About Learning". NSM Teaching Workshop. Univ of Denver: NSM - Univ of Denver.
Sadler, S. E. (2013). One approach to hybrid teaching/learning in a large lecture class. 2013 Teaching with Technology Symposium. Metropolitan State Univ of Denver: Metro State Univ of Denver & eLearning Consortium of Colorado.

Awards

  • PPAPPA Teaching Award, Child Health Associate Program - Univ of Colo Sch of Medicine
  • Minority Recognition Award for Outstanding Faculty, University of Denver
  • Faculty Award for Excellence, NSME - University of Denver
  • Distinguished Teaching Award, University of Denver
  • Faculty Advisor of the Year, Advising Center