Biophysics Seminar

November 5

4:00pm - 5:00pm

Boettcher Auditorium 101

3D, Multicolor and Live-Cell Super-Resolution Microscopy for Cell Biological Research

Joerg Bewersdorf
Professor of Cell Biology and of Biomedical Engineering
Yale University

Abstract: Cell biological research relies heavily on the capabilities of light microscopes to resolve structures or processes of interest at the nanoscale. Dr. Bewersdorf's research group is developing super-resolution technology which achieves down to about 20 nm resolution in 3D – about 10-fold below the diffraction limit of light – and applies them to cell biological questions. In particular, they are focused on improving the 3D resolution, speed, live-cell compatibility, throughput and depth penetration of STED and PALM/STORM microscopes. In this presentation, he will provide an overview of recent developments in my lab relevant for cell biological research. Highlights will include their recent development of multicolor 4Pi-SMS imaging at 20 nm 3D resolution and live-cell applications of STED microscopy to investigate nanoscale dynamics of the endoplasmic reticulum. This speaker declares financial interests in Bruker Corp. and Hamamatsu Photonics.

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