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Michelle Knowles photo

Michelle Knowles

Professor; Chair, Chemistry & Biochemistr

michelle.knowles@du.edu

303-871-6698 (Office)

https://michelleknowles.wixsite.com/knowleslab

Personal

Seeley G. Mudd Building, 2101 E. Wesley Ave. Denver, CO 80208

Professional Biography

Ph.D. Chemistry, University of Oregon, 2003
M.S. Chemistry, University of Oregon, 1999
B.S. Chemistry, University of Michigan-Flint, 1998

Licensure / Accreditations

  • Mental Health First Aid

Professional Affiliations

  • Biophysical Society

Research

http://michelleknowles.wixsite.com/knowleslab

Key Projects

  • CAREER: Development of nanoparticle based niosensors to characterize the role of nanoscale topology in neurotransmission
  • Progress Towards Understanding Neurotransmission: Temporal mapping of Phospholipase D activity in Exocytosis

Featured Publications

Barg, S., Knowles, M. K., Chen, X., Midorikawa, M., & Almers, W. (2010). Syntaxin clusters assemble reversibly at sites of secretory granules in live cells. Proceedings of the National Academy of Science U.S.A., 107(48), 20804–20809.
Knowles, M. K., Barg, S., Wan, L., Midorikawa, M., Chen, X., & Almers , W. (2010). Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers. Proceedings of the National Academy of Science U.S.A., 107(48), 20810–20815.
Black, J. C., Cheney, P. P., Campbell, T., & Knowles, M. K. (2014). Membrane Curvature Based Lipid Sorting Using a Nanoparticle Patterned Substrate. Soft Matter/ RSC, 10(12), 2016–2023.
Alnaas, A. A., Moon, C. L., Alton, M., Reed, S. M., & Knowles, M. K. (2017). Conformational Changes in C-Reactive Protein Affect Binding to Curved Membranes in a Lipid Bilayer Model of the Apoptotic Cell Surface. Journal of Physical Chemistry B, 121(12), 2631–2639.

Awards

  • Faculty Early Career Award (CAREER) , National Science Foundation
  • Marie Curie and Vinnmer Fellow, Vinnova
  • Barton L. Weller Chair, DU NSM