Michelle Knowles

Professor

Faculty
College of Natural Sciences and Mathematics
Chemistry & Biochemistry
Molecular & Cellular Biophysics

michelle.knowles@du.edu

303-871-6698 (Office)

https://michelleknowles.wixsite.com/knowleslab

Personal

Seeley G. Mudd Building, 2101 E. Wesley Ave. Denver, CO 80208

Professional Biography

Ph.D. Chemistry, University of Oregon, 2003
M.S. Chemistry, University of Oregon, 1999
B.S. Chemistry, University of Michigan-Flint, 1998

Professional Affiliations

Biophysical Society

Research

http://michelleknowles.wixsite.com/knowleslab

Key Projects

CAREER: Development of nanoparticle based niosensors to characterize the role of nanoscale topology in neurotransmission
Progress Towards Understanding Neurotransmission: Temporal mapping of Phospholipase D activity in Exocytosis

Featured Publications

Barg, S., Knowles, M. K., Chen, X., Midorikawa, M., & Almers, W. (2010). Syntaxin clusters assemble reversibly at sites of secretory granules in live cells. Proceedings of the National Academy of Science U.S.A., 107(48), 20804-20809.

Knowles, M. K., Barg, S., Wan, L., Midorikawa, M., Chen, X., & Almers , W. (2010). Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers. Proceedings of the National Academy of Science U.S.A., 107(48), 20810-20815.

Black, J. C., Cheney, P. P., Campbell, T., & Knowles, M. K. (2014). Membrane Curvature Based Lipid Sorting Using a Nanoparticle Patterned Substrate. Soft Matter/ RSC, 10(12), 2016-2023.

Wall, K. P., Dillon, R., & Knowles, M. K. (2015). Fluorescence Quantum Yield Measurements of Fluorescent Proteins: A Laboratory Experiment for a Biochemistry or Molecular Biophysics Laboratory Course. Biochemistry and Molecular Biology Education, 43(1), 52-59. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/bmb.20837/abstract

Alnaas, A. A., Moon, C. L., Alton, M., Reed, S. M., & Knowles, M. K. (2017). Conformational Changes in C-Reactive Protein Affect Binding to Curved Membranes in a Lipid Bilayer Model of the Apoptotic Cell Surface. Journal of Physical Chemistry B, 121(12), 2631-2639 .