back

Sandra Eaton

Professor

sandra.eaton@du.edu

303-871-3100 (Office)

http://portfolio.du.edu/seaton

F.W. Olin Hall, 2190 E. Iliff Ave. Denver, CO 80208

What I do

My teaching is primarily in undergraduate and graduate physical chemistry. I run a joint research group with Professor Gareth Eaton. We are involved in multiple collaborative research project including EPR instrument development and application to biochemical problems. I am also the Chair of the Department of Chemistry and Biochemistry

Specialization(s)

electron paramagnetic resonance

Professional Biography

Education
B.A. (Chemistry), Wellesley College, Wellesley, MA 1968
Ph.D (Inorganic Chemistry), Massachusetts Institute of Technology, 1972
Asst. Prof, University of Colorado Denver, 1973 - 1979
Assoc. Prof, University of Colorado Denver, 1979 - 1986
Professor, University of Colorado Denver, 1986 - 1989
Professor, University of Denver, 1989 - present

Degree(s)

  • Ph.D., Inorganic Chemistry, Massachusetts Institute of Technology, 1972
  • BA, Chemistry, Wellesy College, 1968

Professional Affiliations

  • American Chemical Society
  • International EPR Society
  • Phi Beta Kappa

Research

The Eaton group develops new electron paramagnetic resonance (EPR) methods and instrumentation to address significant biochemical and chemical problems. A major current emphasis is on EPR methods to improve sensitivity and solve biomedical problems. In collaboration with research groups at the University of Chicago and University of Maryland we are developing methods for imaging local oxygen in vivo and methods for in vivo study of the physiology of tumors. Our team includes chemists, biochemists, physicists, and engineers. Our instrumentation includes state of the art Bruker BioSpin and locally-constructed spectrometers. Dissemination to the research community, in addition to over 350 research papers and reviews, includes a book on EPR imaging, a book on quantitative EPR, and major book chapters about electron spin relaxation and rapid scan EPR.

Areas of Research

electron paramagnetic resonance
distances between sites in biomolecules
electron spin relaxation times

Key Projects

  • Development of an X-Band Rapid Scan EPR Spectrometer
  • New Nitroxide Spin Labels for Distance Measurements in Biological Systems
  • QLC: EAGER: Toward Magnetic Selectivity with Molecular Clock Qubits

Featured Publications

  • Quantitative EPR
  • Room Temperature Distance Measurements of Immobilized Spin-Labeled Protein by DEER/PELDOR
  • Tabletop 700 MHz EPR Imaging Spectrometer
  • Triarylmethyl Radical: EPR Signal to Noise at Frequencies between 250 MHz and 1.5 GHz and Dependence of Relaxation on Radical and Salt Concentration and on Frequency
  • Relaxation Mechanisms

Presentations

  • Rapid-scan EPR Imaging
  • Digital Saturation Recovery with an Arbitrary Waveform Generator Source
  • Electron Spin Relaxation of Nitroxides Designed for DEER Experiments
  • Field-Reversal Method for Rapid Scan Background Correction
  • Electron Spin Relaxation Times of Spin-Labels without Gem-dimethyl Groups

Awards

  • John Evans Professorship, University of Denver
  • Bruker Prize, Royal Society of London, EPR Discussion Group
  • Colorado Section Award, American Chemical Society, Colorado Section