Sandra Eaton

Professor

Faculty
College of Natural Sciences and Mathematics
Chemistry & Biochemistry
Molecular & Cellular Biophysics

sandra.eaton@du.edu

303-871-3102 (Office)

https://epr-center.du.edu

Personal

Seeley G. Mudd Building, 2101 E. Wesley Ave. Denver, CO 80208

What I do

My teaching is primarily in undergraduate and graduate physical chemistry. I run a joint research group with Professor Gareth Eaton. We are involved in multiple collaborative research project including EPR instrument development and application to biochemical problems. I am also the Chair of the Department of Chemistry and Biochemistry

Specialization(s)

electron paramagnetic resonance

Professional Biography

Education
B.A. (Chemistry), Wellesley College, Wellesley, MA 1968
Ph.D (Inorganic Chemistry), Massachusetts Institute of Technology, 1972
Asst. Prof, University of Colorado Denver, 1973 - 1979
Assoc. Prof, University of Colorado Denver, 1979 - 1986
Professor, University of Colorado Denver, 1986 - 1989
Professor, University of Denver, 1989 - present

Degree(s)

Ph.D., Inorganic Chemistry, Massachusetts Institute of Technology, 1972
BA, Chemistry, Wellesy College, 1968

Professional Affiliations

American Chemical Society
International EPR Society
Phi Beta Kappa

Research

The Eaton group develops new electron paramagnetic resonance (EPR) methods and instrumentation to address significant biochemical and chemical problems. A major current emphasis is on EPR methods to improve sensitivity and solve biomedical problems. In collaboration with research groups at the University of Chicago and University of Maryland we are developing methods for imaging local oxygen in vivo and methods for in vivo study of the physiology of tumors. Our team includes chemists, biochemists, physicists, and engineers. Our instrumentation includes state of the art Bruker BioSpin and locally-constructed spectrometers. Dissemination to the research community, in addition to over 350 research papers and reviews, includes a book on EPR imaging, a book on quantitative EPR, and major book chapters about electron spin relaxation and rapid scan EPR.

Areas of Research

electron paramagnetic resonance

distances between sites in biomolecules

electron spin relaxation times

Key Projects

Development of an X-Band Rapid Scan EPR Spectrometer
New Nitroxide Spin Labels for Distance Measurements in Biological Systems
QLC: EAGER: Toward Magnetic Selectivity with Molecular Clock Qubits

Featured Publications

Eaton, G. R., Eaton, S. S., Barr, D. P., & Weber, R. T. (2010). Quantitative EPR. New York: Springer-Verlag/Wein.

Meyer, V., Swanson, M. A., Clouston, L. J., Boratynski, P., Stein, R. A., Mchaourab, H. S., et al. (2015). Room-temperature distance measurements of immobilized spin-labeled protein by DEER/PELDOR. Biophysical Journal, 108(5), 1213-1219. Retrieved from https://doi.org/10.1016/j.bpj.2015.01.015

Buchanan, L. A., Rinard, G. A., Quine, R., Eaton, S. S., & Eaton, G. R. (2018). Tabletop 700 MHz electron paramagnetic resonance imaging spectrometer. Concepts in Magnetic Resonance, Part B, Magnetic Resonance Engineering, 48(3), e21384. Retrieved from https://doi.org/10.1002/cmr.b.21384

Shi, Y., Quine, R., Rinard, G. A., Buchanan, L., Eaton, S. S., Eaton, G. R., et al. (2017). Triarylmethyl radical: EPR signal to noise at frequencies between 250 MHz and 1.5 GHz and dependence of relaxation on radical and salt concentration and on frequency. Zeitschrift fur Physikalische Chemie, 231(4), 923-937. Retrieved from https://doi.org/10.1515/zpch-2016-0813

Eaton, S. S., & Eaton, G. R. (2018). Relaxation mechanisms. In D. Goldfarb & S. Stoll (Eds.), EPR spectroscopy: Fundamentals and methods (pp. 175-192). John Wiley and Sons.

Presentations

Eaton, S. S., Eaton, G. R., Quine, R., Rinard, G. A., Buchanan, L. A., Shi, Y., et al. (2017). Rapid-scan EPR Imaging. 50th Annual Meeting. Oxford, England: Electron Spin Resonance Group of the Royal Society of Chemistry.

Eaton, S. S., & Eaton, G. R. (2017). Digital Saturation Recovery with an Arbitrary Waveform Generator Source. EPR Present and Future. New Paltz NY: Joint SPP1601/Shared EPR Group.

Eaton, S. S., & Eaton, G. R. (2017). Electron Spin Relaxation of Nitroxides Designed for DEER Experiments. EPR-2017. Morgantown WV.

Woodcock, L. B., Buchanan, L. A., Shi, Y., Eaton, S. S., & Eaton, G. R. (2018). Field-Reversal Method for Rapid Scan Background Correction. 59th Rocky Mountain Conference on Magnetic Resonance. Snowbird, Utah: Rocky Mountain Conference on Analytical Chemistry.

Eaton, S. S., & Eaton, G. R. (2018). Electron Spin Relaxation Times of Spin-Labels without Gem-dimethyl Groups. 59th Rocky Mountain Conference on Magnetic Resonance. Snowbird, Utah: Rocky Mountain Conference on Analytical Chemistry.

Awards

John Evans Professorship, University of Denver
Bruker Prize, Royal Society of London, EPR Discussion Group
Colorado Section Award, American Chemical Society, Colorado Section