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Quantitative Biophysical Approaches to Experimental Cell Biology

Dinah Loerke

This research focuses on quantitative biophysical approaches to experimental cell biology. In particular, we are interested in the study of biological processes at the single cell level through the analysis of spatiotemporal dynamics of subcellular events. Our approach combines fluorescence live-cell microscopy, computational image processing and quantitative and statistical data analysis.

Special emphasis lies on large and heterogeneous data populations, with the goal of extracting mechanistic and molecular information through measurement and inter-correlation of different readouts. The relationship between cytoskeletal dynamics and endocytosis and the integration of biochemical and mechanical signaling at the level of the cell membrane are areas of particular interest.